Recherche et enseignement en architecture, génie architectural, urbanisme

Sommaire

CHAPTER 1:
Introduction
1.1 Normal fetal lung development 11
1.2 Fetal lung growth regulation 16
1.3 Purpose of the thesis 18
1.4 Content of the thesis 19

CHAPTER 2:
Pulmonary Hypoplasia (PH)
2.1 Definition 21
2.2 Epidemiology 23
2.3 Factors adversely affecting lung growth leading to PH 24
2.3.1 Reduction in intrathoracic space 25
2.3.1.1 Congenital diaphragmatic hernia (CDH) 25
2.3.1.2 Congenital cystic adenomatoid malformation
(CPAM) 32
2.3.1.3 Bronchopulmonary sequestration (BPS) 37
2.3.1.4 Fetal pleural effusions 39
2.3.1.5 Skeletal disorders 41
2.3.2 Reduction in fetal breathing movements (FBM) 43
2.3.2.1 Anterior abdominal wall defects (AWD) 44
2.3.2.2 Reduction in amniotic and lung fluid volume 61

CHAPTER 3:
Prenatal management of pulmonary hypoplasia and potential
therapeutic approach
3.1 Pulmonary hypoplasia: prenatal diagnosis and evaluation 65
3.2 Pulmonary hypoplasia in lower obstructive uropathies
(LUTO) 69
3.3 Pulmonary hypoplasia in CDH 85
3.3.1 Role of left main bronchus occlusion
in the prenatal treatment of CDH 85

CHAPTER 4:
Summary, general discussion and perspectives 117
REFERENCES 125
ADDITIONAL CONTRIBUTIONS 143