Searching for longevity determinants:

following survival of newborns in a in-land village in Sardinia (1866-2006)
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The scientific debate on longevity and its determinants is lively and involves researchers from different some people live longer than others is not an easy task. Variables that are shown to be significant for longer survival in certain populations are


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Spécifications


Éditeur
Presses universitaires de Louvain
Auteur
Luisa Salaris,
Collection
Thèses de la Faculté des sciences économiques, sociales, politiques et de communication
Langue
anglais
BISAC Subject Heading
BUS000000 BUSINESS & ECONOMICS
Code publique Onix
06 Professionnel et académique
CLIL (Version 2013-2019 )
3283 SCIENCES POLITIQUES
Date de première publication du titre
01 janvier 2009
Subject Scheme Identifier Code
Classification thématique Thema: Sciences politiques et théorie
Type d'ouvrage
Thèse

Livre broché


Date de publication
01 janvier 2009
ISBN-13
978-2-87463-145-0
Ampleur
Nombre de pages de contenu principal : 180
Code interne
79645
Format
16 x 24 x 1 cm
Poids
300 grammes
Prix
22,00 €
ONIX XML
Version 2.1, Version 3

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Sommaire


1 Introduction ..............................................................................................1
1.1 Longevity studies in Sardinia..................................................................................2
1.2 Aim, objectives and study design............................................................................5
1.3 Thesis organization .................................................................................................6
2 The secret of longevity: Genes, Fountain of Youth or Shangri-la?.....9
2.1 The possible determinants of longevity ..................................................................9
2.1.1 Sex..................................................................................................................12
2.1.2 Familial transmission of longevity................................................................14
2.1.3 Early-life conditions.......................................................................................22
2.1.4 Other pieces of the puzzle ..............................................................................26
2.2 An integrated model for the study of longevity ...................................................30
2.3 Conclusion.............................................................................................................32
3 The municipality of Villagrande Strisaili: from past to present .......35
3.1 The population of Villagrande Strisaili: from past to present ...............................35
3.2 General demographic trends..................................................................................40
3.3 Socio-economic conditions ...................................................................................44
3.4 Life trajectories of newborns in Villagrande Strisaili (1866-1915) ......................49
3.5 Conclusion.............................................................................................................52
4 Data: collection, sources, and quality...................................................55
4.1 Data collection.......................................................................................................55
4.2 Data sources ..........................................................................................................57
4.3 Data Quality ..........................................................................................................61
4.4 Conclusion.............................................................................................................64
5 The VI-llagrande L-ongevity D-atabase (VILD).................................65
5.1 Family reconstructed databases: review and strong points ...................................65
5.2 The creation of the VI-llagrande L-ongevity D-atabase (VILD) ..........................67
5.2.1 Selection of VILD newborns..........................................................................67
5.2.2. The issue of "non-local" newborns: implications of exclusion.....................71
5.2.3 Individual linkage procedure and final coverage of known survival for VILD
newborns .................................................................................................................74
5.2.4 Handling partial information: censoring strategy in the VILD......................77
5.2.5 Complete cases and partial information: implications on the analysis ..........81
5.3 The fifty-year old VILD newborns group .............................................................83
5.4 Conclusion.............................................................................................................85
6 Methods ...................................................................................................87
6.1 Definition of event, state space and censoring......................................................87
6.2 Survival analysis methods.....................................................................................88
6.3 The Cox proportional hazard model......................................................................90
6.4 The VILD Cox proportional hazard model ...........................................................93
6.5 Conclusion.............................................................................................................94
7 Empirical Model .....................................................................................95
7.1 The process leading to the empirical model..........................................................95
7.2 The coding procedure............................................................................................96
7.3 The operationalisation of variables .......................................................................98
7.3.1 Gender ..........................................................................................................103
7.3.2 Familial transmission of longevity...............................................................103
7.3.3 Environmental conditions ............................................................................109
7.4 Conclusion...........................................................................................................110
8 Mortality trajectories among the VILD newborns ...........................113
8.1 Infant and child mortality....................................................................................113
8.2 Mortality from 5 to 18 years old .........................................................................119
8.3 Young adult mortality: the role of maternal mortality and accidental deaths .....121
8.4 From 50 years old to oldest-old mortality...........................................................124
8.5 Life expectancy: estimation and comparison ......................................................126
8.6 Conclusion...........................................................................................................130
9 Searching for longevity determinants ................................................133
9.1 Differential survival among defined groups of fifty-year-old and over VILD
newborns ...................................................................................................................133
9.2 Identification of possible individual determinants of longevity..........................146
9.3 Conclusion...........................................................................................................158
10 Conclusions .........................................................................................161
References ................................................................................................165